Animal Models for the Study of Human Disease

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease.

Animal Models for the Study of Human Disease

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity or disagreement, and suggests considerations that are relevant for resolution of these issues. Recommendations are offered for participation by investigators in ethical discussion of their work, and of biomedical animal research generally. The general themes of the chapter are that investigators play the primary role in assuring the ethical conduct of biomedical animal research, and that a crucial foundation of ethical animal research is sound science.

More Books:

Animal Models for the Study of Human Disease
Language: en
Pages: 1108
Authors: Jerrold Tannenbaum
Categories: Medical
Type: BOOK - Published: 2013-05-29 - Publisher: Elsevier Inc. Chapters

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying
Animal Models for the Study of Human Disease
Language: en
Pages: 1108
Authors: Li Chen, Richard P. Shannon, You-Tang Shen
Categories: Medical
Type: BOOK - Published: 2013-05-29 - Publisher: Elsevier Inc. Chapters

With advances in molecular and genomic research offering novel insights into cardiovascular diseases, many transgenic animal models have been recently developed and characterized. Currently, more than 90 percent of all laboratory animal experiments are conducted in mice and rats. Although there are many scientific advantages to using small animal models,
Animal Models for the Study of Human Disease
Language: en
Pages: 1108
Authors: JoEllen Welsh
Categories: Medical
Type: BOOK - Published: 2013-05-29 - Publisher: Elsevier Inc. Chapters

Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive molecular and cellular research, the mortality rate remains high. Preclinical testing of new strategies to prevent the emergence of invasive disease and to effectively treat existing disease is dependent on appropriate in vivo models. The challenges with
Animal Models for the Study of Human Disease
Language: en
Pages: 1108
Authors: Lixin Kan
Categories: Medical
Type: BOOK - Published: 2013-05-29 - Publisher: Elsevier Inc. Chapters

Bone disorders have a major impact on general population and cover a broad spectrum of diseases. At one end of the spectrum are the common disorders that are featured with age related progressive degeneration, and at the other end are the rare but serious congenital abnormities. Deeper understanding of the
Animal Models for the Study of Human Disease
Language: en
Pages: 1108
Authors: Bernhard Aigner, Barbara Kessler, Nikolai Klymiuk, Mayuko Kurome, Simone Renner, Annegret Wünsch, Eckhard Wolf
Categories: Medical
Type: BOOK - Published: 2013-05-29 - Publisher: Elsevier Inc. Chapters

Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics